Hundreds of jobs have been pledged in a series of investments in the technology, manufacturing and healthcare sectors.
The largest will see GE pump €150m into creating four factories in a biopharmaceutical manufacturing campus in Cork.
The units will provide state-of-the-art space for making next-generation medicines and healthcare products.
GE already employs 600 people in Cork and 46,000 worldwide.
The firm said it expects the site at Loughbeg, Ringaskiddy to provide jobs for 400 workers in biopharma companies and another 100 employed directly by itself.
Building work is due to get under way in the middle of next year.
The investment is backed by IDA Ireland and about 800 construction staff will work on the project.
Jobs Minister Mary Mitchell O’Connor said: “This is a further testament to our talented workforce. All investment and jobs created has a positive knock-on effect on the wider region.”
Meanwhile, speciality pharmaceutical company Mallinckrodt is to invest €10m in a state-of-the-art R&D facility in Blanchardstown, Dublin to create 40 jobs.
Austrialian company Oneview Healthcare, which develops software to improve patient experience in the healthcare sector, is to create 100 jobs in its Dublin office.
The positions will be filled over the next two years.
In another announcement software company MathWorks is to create 50 jobs in Galway, with the opening of a new sales and services centre in the city.
Today’s announcements could mean up to 600 new jobs across Ireland.
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